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1. Madison Wynne El-Saadi, Xinli Tian, Mychal Grames, Michael Ren, Kelsea Keys, Hanna Li, Erika Knott, Hong Yin, Shile Huang, Xiao-Hong Lu,  Tracing brain genotoxic stress in Parkinson’s disease with a novel single-cell genetic sensor. Science Advances, Vol 8, Issue 15 • DOI: 10.1126/sciadv.abd1700, 2022.

2.Li J, Li C, Loreno EG, Miriyala S, Panchatcharam M, Lu XH, Sun H. Chronic Low-Dose Alcohol Consumption Promotes Cerebral Angiogenesis in Mice. Front Cardiovasc Med. 2021 Nov 17;8:681627. doi: 10.3389/fcvm.2021.681627. PMID: 34869620; PMCID: PMC8635527.


3. Barzegar M, Wang Y, Eshaq RS, Yun JW, Boyer CJ, Cananzi SG, White LA, Chernyshev O, Kelley RE, Minagar A, Stokes KY, Lu XH, Alexander JS. Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow. EBioMedicine. 2020 Dec 18;63:103161. doi: 10.1016/j.ebiom.2020.103161. PMID: 33348090 


4. Xinli Tian, Adam Richard,  Madison Wynne El-Saadi, Aakriti Bhandari,  Isabella Van Savage, Kevlyn Holmes, Ronald L. Klein, Donard Dwyer, Nicholas E. Goeders,  X. William Yang, Xiao-Hong Lu*. Dosage sensitivity intolerance of VIPR2 microduplication is disease causative to manifest schizophrenia-like phenotypes in a novel BAC transgenic mouse model. Molecular Psychiatry-Nature, 8/23/ 2019:  link ; Spectrum News; Great Daily; Sohu; Brain News

5. Richard AD, Lu XH. “Teaching old dogs new tricks”: targeting neural extracellular matrix for normal and pathological aging-related cognitive decline. Neural Regen Res 2019;14:578-81. Link


6. Adam Richard; Xinli Tian; Madison W El-Saadi; Xiao-Hong Lu. Erasure of striatal chondroitin sulfate proteoglycan associated extracellular matrix rescues aging-dependent decline of motor learning, Neurobiology of Aging 2018 Jul 23;71:61-71. doi: 10.1016/j.neurobiolaging.2018.07.008. link


7. David J. McGee, Xiao-Hong Lu, and Elizabeth A. Disbrow, Stomaching the possibility of a pathogenic role for Helicobacter pylori in Parkinson’s disease. Journal of Parkinson's disease, 2018;8(3):367-374. doi: 10.3233/JPD-181327. Press Release, ScienceDaily, Parkinsonsnewstoday


8. Grames, M. S., Dayton, R. D., Jackson, K. L., Richard, A. D., Lu, X., Klein, R. L. Cre-dependent AAV vectors for highly targeted expression of disease-related proteins and neurodegeneration in the substantia nigra. FASEB J. 2018 Mar 7:fj201701529RR


9. Lu XH, Yang XW. Genetically-directed Sparse Neuronal Labeling in BAC Transgenic Mice through Mononucleotide Repeat Frameshift. Sci Rep. 2017 Mar 8;7:43915.


10. Xu, J., Bernstein, A., Wong, A., Lu, X., Khoja, S., Yang, X.W., Davies, D.L., Micevych, P., Sofroniew, M.V., Khakh, B.S. (2016). P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus. J Neuroscience. 36: 8902-8920.


11. Langfelder, P., Cantle, J.P., Chatzopoulou, D., Wang, N., Gao, F., Al-Ramahi, I., Lu, X.H., Ramos, E.M., El-Zein, K., Zhao, Y., Deverasetty, S., Tebbe, A., Schaab, C., Lavery, D.J., Howland, D., Kwak, S., Botas, J., Aaronson, J.S., Rosinski, J., Coppola, G., Horvath, S., and Yang, X.W. (2016). Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nature Neurosci. 19: 623-633.


12. Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Sci Transl Med. 2015; Highlighted in Nat Rev Drug Discov. Huntington Disease: Banking on ATM. 2015;14(2):92-3; Selected as the most influential paper of 2014-2015 by HD insight.


13. Veldman, M.B., Rios-Galdamez, Y., Lu, X.H., Gu, X., Qin, W., Li, S., Yang, X.W. and Lin, S. (2015). The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington’s disease model. Mol Neurodegener. 10: 1-16.


14. Peñagarikano O, Lázaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Sci Transl Med. 2015 21;7(271):271ra8.


15. Wang N, Gray M, Lu XH, Cantel J,  Greiner E, Gu X, Shirasaki D, Cepeda C, Holey S. Dong H, Levine M, Yang XW.  Neuronal Targets of Mutant Huntingtin Genetic Reduction to Prevent HD Pathogenesis in Mice. Nature Medicine 20, 536–541 (2014)


16.   Wang N*, Lu XH*, Sandova S, Yang XW. An Independent Study of the Preclinical Efficacy of C2-8 in the R6/2 Transgenic Mouse Model of Huntington's Disease. Journal of Huntington's disease, 2(4): 1879-6397, 2013 (*Co-First author)


17. Haustein MD, Kracun S, Lu XH, Jackson-Weaver O, Tong X, Xu J, Yang XW , Marvin J, Looger  L &  Khakh BS: Conditions and constraints for astrocyte calcium excitability in a neuronal circuit. Neuron 2014 Apr 16;82(2):413-29.


18. Lu XH and Yang XW. “Huntingtin Holiday”: Progress towards an antisense therapy for Huntington’s disease. Neuron, 74(6):964-6, 2012


19. Cantle, J.P., Lu, X.H., Gu, X.F., Yang, X.W. Cellular and molecular mechanisms implicated in pathogenesis of selective neurodegeneration in Huntington’s Disease. Frontiers in Biology, 459-476, 2012


20. Yang XW, Lu XH, Molecular and Cellular Basis of OCD-like Behaviors: Emerging View from Mouse Models. Current Opinion in Neurology, 114-118, 2011.


21. Tao J, Wu H, Lin Q, Wei W, Lu XH, Cantle JP, Ao Y, Olsen RW, Yang XW, Mody I, Sofroniew MV, Sun YE. Deletion of astroglial dicer causes non-cell-autonomous neuronal dysfunction and degeneration. J Neuroscience 31:8306-19, 2011.


22. Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, Hernandez D, Sulzer D, Jackson GR, Maidment NT, Chesselet MF, Yang XW. BAC transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. J. Neuroscience, 29: 1962–1976, 2009 (     Highlighted by J Neurosci 2009 Jun 10;29(23):7392-4. Mice expressing mutant parkin exhibit hallmark features of Parkinson's disease, Highlighted in SciBX: Science-Business eXchange, Feb, 2009)


23. Lu XH. BAC to degeneration: Bacterial Artificial Chromosome (BAC)-mediated transgenesis for modeling basal ganglia neurodegenerative disorders. Int Rev Neurobiol. 2009;89:37-56


24. Gray M, Shirasaki D, Cepeda Carlos C, Andre VM, Wilburn B, Lu XH, Tao J, Yamazaki Y, Li SH, Sun YE, Li XJ, Levine MS, Yang XW. Full length human mutant Huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J. Neuroscience, 28: 6182-95, 2008


25. Zuo J, Liu Z, Ouyang X, Liu H, Hao Y, Xu L, Lu XH. Distinct neurobehavioral consequences of prenatal exposure to sulpiride (SUL) and risperidone (RIS) in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):387-97. 2007


26. Lu XH, Dwyer DS. Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways. J Mol Neurosci. 2005;27(1):43-64.


27. Ardizzone TD, Lu XH, Dwyer DS. Calcium-independent inhibition of glucose transport in PC-12 and L6 cells by calcium channel antagonists. Am J Physiol Cell Physiol, 2002 Aug;283(2):C579-86


28. Lu XH, Bradley RJ and Dwyer DS. Olanzapine produces trophic effects in vitro and stimulates phosphorylation of Akt/PKB, ERK1/2, and the mitogen-activated protein kinase p38. Brain Res. 2004 Jun 11;1011 (1):58-68.


29. Dwyer DS, Lu XH, Bradley RJ. Cytotoxicity of conventional and atypical antipsychotic drugs in relation to glucose metabolism. Brain Res. 2003 May 2;971(1):31-9.


30. Dwyer DS, Lu XH, Freeman A M. Neuronal glucose metabolism and schizophrenia: therapeutic prospects? Expert Rev. Neurotherapeutics. 2002    


31. Lu XH, Li LJ, Li CQ, Luo XG. Effects of psychological stress on immediate gene c-fos expression and HPA axis regulation in rats. Chinese Journal of Mental Health. 2000; 14(1):10-13 


32.  Lu XH, Li LJ. Immediate gene c-fos and the molecular mechanism of psychological stress. Chinese Journal of Behavioral Medical Science. 1998, 7(1): 77-79


33. Lu XH, Li LJ, Li CQ, Luo XG. Potential anxiolytic role of c-fos antisense oligonucleotide in social-defeated rats. Bulletin of Xiangya Medical University, 2000 Dec 28;25(6):535-8


34.  Lu XH. Antisense technology and the application in psychopharmacology. Journal of International Psychiatry. 1997, 24(4). 222-227


35.  Lu XH. Social construction of brain.  Journal of International Psychiatry.  1996, 23(3). 167-171


36. Chapter II, Neuropsychopharmacolog of Child and Adolescent Psychiatry. In Textbook of Child and Adolescent Psychiatry, Hunan Science and Technology Publisher, China (2013) 


37. Yang XW and Lu XH. Chapter 19. The BAC transgenic approach to study Parkinson’s disease in mice. In “Parkinson’s Disease: Pathogenic and therapeutic insights from toxin and genetic models” (Edited by Richard Nass and Serge Przeborski). Elsevier: San Diego, 2008


38. Lu XH, Dwyer DS., Chapter IX.  Neurotrophic effects of Psychoactive drugs: Significance for schizophrenia and other neurodevelopmental disorders. in Trends in Schizophrenia Research, Nova Science Publisher, New York, 2005

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