Genetic Animal Models of Neuropsychiatric Disorders
To dissect pathogenic mechanisms and to identify therapeutic targets for neuropsychiatric disorders (Parkinson’s disease, Huntington’s disease, Schizophrenia, Depression, Stress and Drug Addiction) in genetically-engineered animal models generated using gene targeting/editing (CRISPR/Cas9) and Bacterial Artificial Chromosome (BAC) transgenesis
Molecular Genetic Tools for Neurocircuit and Single Neuron Manipulation
Employ molecular genetic tools (Designer Receptors Exclusively Activated by Designer Drug (DREADD), optogenetics, DHFR etc) to pinpoint the mechanism of action of pharmacotherapies to genetically defined neuronal population or circuits
Drug Discovery and Preclinical Trial
In vivo single neuron pharmacology and preclinical trial to study therapeutics for basal ganglia related neuropsychiatric disorders.