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Molecular Genetic Approach to Study Environmental Origins of Neuropsychiatric Disorders
To study environmental origins of neuropsychiatric disorders (Parkinson’s , Alzheimer's and Huntington’s diseases, Schizophrenia, Depression, Stress, and Drug Addiction) in genetically-engineered animal models generated using gene targeting/editing (CRISPR/Cas9) and Bacterial Artificial Chromosome (BAC) transgenesis
Development of Novel Genetic Technologies for Neurocircuit and Single-Neuron Manipulation
Development of novel genetic neurotechnologies to probe structure and function of nervous system, and to pinpoint the mechanism of action of pharmacotherapies to genetically defined neuronal population or circuits
Gene Therapy, Drug Discovery, and Preclinical Trial
In vivo single neuron pharmacology and preclinical trial to study therapeutics for basal ganglia related neuropsychiatric disorders.